Cognitive and affective mechanisms of pain and fatigue in multiple sclerosis.

ABSTRACT:

Objective

To examine the extent to which pain catastrophizing, fatigue catastrophizing, positive affect, and negative affect simultaneously mediated the associations between common symptoms of multiple sclerosis (MS; i.e., pain, fatigue) and impact on daily life, depressive symptoms, and resilience.

Method

Participants were community-dwelling adults with MS (N = 163) reporting chronic pain, fatigue, and/or moderate depressive symptoms. Multiple mediation path analysis was used to model potential mediators of pain and fatigue separately, using baseline data from a randomized controlled trial comparing two symptom self-management interventions.

Results

In the pain model, pain catastrophizing was a mediator of pain intensity with pain interference and depression. Negativ

SUBMITTER: Arewasikporn A 

PROVIDER: S-EPMC5962424 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature