Transport of the pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier: implications for migraine.

ABSTRACT:

Background

Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology. Understanding the function of the blood-brain barrier (BBB) in relation to PACAP is important to the understand the mechanisms behind PACAP-induced migraine attacks, but also to develop antimigraine drugs targeting the PACAP receptors Here, we aim to review the transport ability of PACAP across the BBB.

Methods

We performed a systematic literature search on PubMed to identify studies reporting original data on PACAP and BBB. The search was finalized in July 2017.

Results

The literature search identified 96 papers of which 11 contained relevant data. In addition, two papers were known to be relevant and were incl

SUBMITTER: Amin FM 

PROVIDER: S-EPMC5962479 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature