Differential protein profiling as a potential multi-marker approach for obese patients with heart failure: A retrospective study.

ABSTRACT: Identification of novel circulating biomarkers predicting death and major cardio-metabolic events in obese patients with heart failure (HF) remains a research priority. In this study, we compared multi-marker profile of non-obese (NOB) and obese (OB) HF patients in relation to mortality outcome. The new multiplex proximity extension assay technology was used to analyze the levels of 92 proteins in plasma samples from HF patients according to body mass index (BMI) categories. At 2-year follow-up, all-cause mortality rates were significantly greater in NOB patients (BMI < 30 kg/m²) compared to the OB patients (BMI > 30 kg/m²) with HF (odds ratio 26; 95% CI: 1.14-624, p < 0,04). Quantitative proteomic analysis revealed thirteen distinct proteins expression profiles of OB

SUBMITTER: Timotin A 

PROVIDER: S-EPMC5962559 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature