Ontology highlight
ABSTRACT:
SUBMITTER: Faria M
PROVIDER: S-EPMC5962567 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Scientific reports 20180521 1
Acute exposure to acrylamide (ACR), a type-2 alkene, may lead to a ataxia, skeletal muscles weakness and numbness of the extremities in human and laboratory animals. In the present manuscript, ACR acute neurotoxicity has been characterized in adult zebrafish, a vertebrate model increasingly used in human neuropharmacology and toxicology research. At behavioral level, ACR-treated animals exhibited "depression-like" phenotype comorbid with anxiety behavior. At transcriptional level, ACR induced do ...[more]