Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions.

ABSTRACT: The transcriptional responses of yeast cells to diverse stresses typically include gene activation and repression. Specific stress defense, citric acid cycle and oxidative phosphorylation genes are activated, whereas protein synthesis genes are coordinately repressed. This view was achieved from comparative transcriptomic experiments delineating sets of genes whose expression greatly changed with specific stresses. Less attention has been paid to the biological significance of 1) consistent, albeit modest, changes in RNA levels across multiple conditions, and 2) the global gene expression correlations observed when comparing numerous genome-wide studies. To address this, we performed a meta-analysis of 1379 microarray-based experiments in yeast, and identified 1388 blocks of RNAs whose exp

SUBMITTER: Talavera D 

PROVIDER: S-EPMC5962585 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature