Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

ABSTRACT: We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese and other East Asian populations. We identified 65 SNPs with P values < 10^-4 located within the HLA class I region and three SNPs were genotyped in three independent population-based replication sets. Meta-analysis confirmed the association of the three SNPs (rs2523961: OR = 1.73, P = 7.50 × 10^-12; rs1110446: OR = 1.79, P = 1.66 × 10^-13; and rs3094137: OR = 1.73, P = 7.09 × 10^-9). We then performed two-field HLA genotype imputation

SUBMITTER: Sawai H 

PROVIDER: S-EPMC5962604 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature