Integration of large-scale data for extraction of integrated Arabidopsis root cell-type specific models.

ABSTRACT: Plant organs consist of multiple cell types that do not operate in isolation, but communicate with each other to maintain proper functions. Here, we extract models specific to three developmental stages of eight root cell types or tissue layers in Arabidopsis thaliana based on a state-of-the-art constraint-based modeling approach with all publicly available transcriptomics and metabolomics data from this system to date. We integrate these models into a multi-cell root model which we investigate with respect to network structure, distribution of fluxes, and concordance to transcriptomics and proteomics data. From a methodological point, we show that the coupling of tissue-specific models in a multi-tissue model yields a higher specificity of the interconnected models with respect to network

SUBMITTER: Scheunemann M 

PROVIDER: S-EPMC5962614 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature