Age Related Changes in Topological Properties of Brain Functional Network and Structural Connectivity.

ABSTRACT: Introduction: There are still uncertainties about the true nature of age related changes in topological properties of the brain functional network and its structural connectivity during various developmental stages. In this cross- sectional study, we investigated the effects of age and its relationship with regional nodal properties of the functional brain network and white matter integrity. Method: DTI and fMRI data were acquired from 458 healthy Chinese participants ranging from age 8 to 81 years. Tractography was conducted on the DTI data using FSL. Graph Theory analyses were conducted on the functional data yielding topological properties of the functional network using SPM and GRETNA toolbox. Two multiple regressions were performed to investigate the effects of age on no

SUBMITTER: Shah C 

PROVIDER: S-EPMC5962656 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature