The Claudin Family Protein FigA Mediates Ca²⁺ Homeostasis in Response to Extracellular Stimuli in Aspergillus nidulans and Aspergillus fumigatus.

ABSTRACT: The claudin family protein Fig1 is a unique fungal protein that is involved in pheromone-induced calcium influx and membrane fusion during the mating of Saccharomyces cerevisiae and Candida albicans. Whether and how Fig1 regulates Ca²⁺ homeostasis in response to extracellular stimuli is poorly understood. Previously, we found Aspergillus nidulans FigA, a homolog of Fig1 in S. cerevisiae, similar to the high-affinity calcium uptake system, is required for normal growth under low-Ca²⁺ minimal medium. In this study, using the calcium-sensitive photoprotein aequorin to monitor cytosolic free calcium concentration ([Ca²⁺]_c) in living cells, we found that the FigA dysfunction decreases the transient [Ca²⁺]_c</

SUBMITTER: Qian H 

PROVIDER: S-EPMC5962676 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature