Consumption of Goats' Milk Protects Mice From Carbon Tetrachloride-Induced Acute Hepatic Injury and Improves the Associated Gut Microbiota Imbalance.

ABSTRACT: Drugs used to treat liver diseases have serious side effects; it is important to search for safe functional foods with hepatoprotective functions and few side effects. In this study, potential hepatoprotective effects of goats' milk and cows' milk on mice with CCl₄-induced acute hepatic injury were evaluated. We also elucidated the role of goats' and cows' milk on the regulation of CCl₄-induced gut microbiota imbalance. In mice with liver damage induced by CCl₄, administration of goats' milk for 7 days prior to injection of CCl₄ had beneficial effects on the indicators of liver damage within 1 day: the area of liver necrosis was small; activity of alanine transaminase (ALT) and aspartate transaminase (AST) and expression of the genes CYP2E1

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5962680 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature