The Loss of Expression of a Single Type 3 Effector (CT622) Strongly Reduces <i>Chlamydia trachomatis</i> Infectivity and Growth.

ABSTRACT: Invasion of epithelial cells by the obligate intracellular bacterium Chlamydia trachomatis results in its enclosure inside a membrane-bound compartment termed an inclusion. The bacterium quickly begins manipulating interactions between host intracellular trafficking and the inclusion interface, diverging from the endocytic pathway and escaping lysosomal fusion. We have identified a previously uncharacterized protein, CT622, unique to the Chlamydiaceae, in the absence of which most bacteria failed to establish a successful infection. CT622 is abundant in the infectious form of the bacteria, in which it associates with CT635, a putative novel chaperone protein. We show that CT622 is translocated into the host cytoplasm via type three secretion throughout the developmental cycle

SUBMITTER: Cosse MM 

PROVIDER: S-EPMC5962693 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature