Hypoxia Aggravates Inactivity-Related Muscle Wasting.

ABSTRACT: Poor musculoskeletal state is commonly observed in numerous clinical populations such as chronic obstructive pulmonary disease (COPD) and heart failure patients. It, however, remains unresolved whether systemic hypoxemia, typically associated with such clinical conditions, directly contributes to muscle deterioration. We aimed to experimentally elucidate the effects of systemic environmental hypoxia upon inactivity-related muscle wasting. For this purpose, fourteen healthy, male participants underwent three 21-day long interventions in a randomized, cross-over designed manner: (i) bed rest in normoxia (NBR; P_iO₂ = 133.1 ± 0.3 mmHg), (ii) bed rest in normobaric hypoxia (HBR; P_iO₂ = 90.0 ± 0.4 mmHg) and ambulatory confinement in normobaric hypoxia

SUBMITTER: Debevec T 

PROVIDER: S-EPMC5962751 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature