Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis.

ABSTRACT:

Background

Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent tonsillitis. We investigated the differences in virus detection and T cell and interferon gene expression in patients undergoing tonsillectomy due to tonsillar hypertrophy or recurrent tonsillitis.

Methods

Tonsils of 89 surgical patients with tonsillar hypertrophy (n = 47) or recurrent tonsillitis (n = 42) were analysed. Patients were carefully characterized clinically. Standard questionnaire was used to asses preceding and allergy symptoms. Respiratory viruses were analysed in tonsils and nasopharynx by PCR.

SUBMITTER: Mikola E 

PROVIDER: S-EPMC5963068 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature