Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD.

ABSTRACT:

Background

The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suPAR in predicting risk of death following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has never been studied. We hypothesized that increased suPAR is an independent predictor of short-term mortality in patients admitted to hospital with COPD or acute respiratory failure.

Methods

This retrospective cohort study from a university hospital in the Capital Region of Denmark included 2838 acutely admitted medical patients with COPD as primary (AECOPD) or secondary diagnosis, who had plasma suPAR measured at the time of admission between N

SUBMITTER: Godtfredsen NS 

PROVIDER: S-EPMC5963104 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature