VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process.

ABSTRACT:

Objective

During degeneration of the intervertebral disc ingrowth of blood vessels and nerves into the disc are associated with back pain. Vascular endothelial growth factors promote vasculogenesis by binding to the membrane vascular endothelial growth factor receptor 1, while shorter soluble forms of this receptor can inhibit vascularization. We hypothesized that membrane and soluble receptor forms might change between stages of intervertebral disc degeneration.

Results

Expression of soluble and membrane forms of vascular endothelial growth factor receptor 1 in human degenerated intervertebral discs and healthy bovine caudal discs was assessed by qRT-PCR and immunoblot. Comparative microarray meta-analysis across disc degeneration grades showed that membrane and soluble for

SUBMITTER: Capossela S 

PROVIDER: S-EPMC5963106 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature