Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration.

ABSTRACT: Hematopoietic regeneration following chemotherapy may be distinct from regeneration following radiation. While we have shown that epidermal growth factor (EGF) accelerates regeneration following radiation, its role following chemotherapy is currently unknown. We sought to identify EGF as a hematopoietic growth factor for chemotherapy-induced myelosuppression. Following 5-fluorouracil (5-FU), EGF accelerated hematopoietic stem cell regeneration and prolonged survival compared with saline-treated mice. To mitigate chemotherapy-induced injury to endothelial cells in vivo, we deleted Bax in VEcadherin⁺ cells (VEcadherinCre;Bax^FL/FL mice). Following 5-FU, VEcadherinCre;Bax^FL/FL mice displayed preserved hematopoietic stem/progenitor content compared with litterma

SUBMITTER: Piryani SO 

PROVIDER: S-EPMC5963258 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature