Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women.

ABSTRACT:

Purpose

Vitamin D has been implicated in lowering lung cancer risk, but serological data on the association among never-smoking women are limited. We report results examining the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with lung cancer risk among female never smokers. We also examined whether the association was modified by vitamin D supplementation and serum vitamin A concentrations.

Methods

In the Women's Health Initiative, including the calcium/vitamin D (CaD) Trial, we selected 298 incident cases [191 non-small cell lung cancer (NSCLC) including 170 adenocarcinoma] and 298 matched controls of never smokers. Baseline serum 25(OH)D was assayed by a chemiluminescent method. Logistic regression was used to estimate odds ratios (ORs) for quartiles an

SUBMITTER: Cheng TD 

PROVIDER: S-EPMC5963264 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature