Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study.

ABSTRACT:

Introduction

Various definitions of bleeding have been used in perioperative studies without systematic assessment of the diagnostic criteria for their independent association with outcomes important to patients. Our proposed definition of bleeding impacting mortality after noncardiac surgery (BIMS) is bleeding that is independently associated with death during or within 30 days after noncardiac surgery. We describe our analysis plan to sequentially 1) establish the diagnostic criteria for BIMS, 2) estimate the independent contribution of BIMS to 30-day mortality and 3) develop and internally validate a clinical prediction guide to estimate patient-specific risk of BIMS.

Methods

In the Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (VISION) study, we prospe

SUBMITTER: Roshanov PS 

PROVIDER: S-EPMC5963363 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature