Roles of microglia in brain development, tissue maintenance and repair.

ABSTRACT: The emerging roles of microglia are currently being investigated in the healthy and diseased brain with a growing interest in their diverse functions. In recent years, it has been demonstrated that microglia are not only immunocentric, but also neurobiological and can impact neural development and the maintenance of neuronal cell function in both healthy and pathological contexts. In the disease context, there is widespread consensus that microglia are dynamic cells with a potential to contribute to both central nervous system damage and repair. Indeed, a number of studies have found that microenvironmental conditions can selectively modify unique microglia phenotypes and functions. One novel mechanism that has garnered interest involves the regulation of microglial function by microRNAs,

SUBMITTER: Michell-Robinson MA 

PROVIDER: S-EPMC5963417 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature