Genome-wide multi-omics profiling of the 8p11-p12 amplicon in breast carcinoma.

ABSTRACT: Genomic instability contributes to the neoplastic phenotype by deregulating key cancer-related genes, which in turn can have a detrimental effect on patient outcome. DNA amplification of the 8p11-p12 genomic region has clinical and biological implications in multiple malignancies, including breast carcinoma where the amplicon has been associated with tumor progression and poor prognosis. However, oncogenes driving increased cancer-related death and recurrent genetic features associated with the 8p11-p12 amplicon remain to be identified. In this study, DNA copy number and transcriptome profiling data for 229 primary invasive breast carcinomas (corresponding to 185 patients) were evaluated in conjunction with clinicopathological features to identify putative oncogenes in 8p11-p12 amplified s

SUBMITTER: Parris TZ 

PROVIDER: S-EPMC5963621 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature