Lineage-specific epitope profiles for HPAI H5 pre-pandemic vaccine selection and evaluation.

ABSTRACT:

Background

Multiple highly pathogenic avian influenza (HPAI) H5 viruses continue to co-circulate. This has complicated pandemic preparedness and confounded effective vaccine candidate selection and evaluation.

Objectives

In this study, we aimed to predict and map the diversity of CD8+ T-cell epitopes among H5 hemagglutinin (HA) gene lineages to estimate CD8+ T-cell immunity in humans induced by vaccine candidates.

Methods

A dataset consisting of 1125 H5 HA sequences collected between 1996 and 2017 from avian and humans was assembled for phylogenetic and lineage-specific epitope analyses. Conserved epitopes were predicted from WHO-endorsed vaccine candidates and representative clade-defining strains by pairwise comparison with Immune Epitope Database (IEDB). The distri

SUBMITTER: Qiu X 

PROVIDER: S-EPMC5963872 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature