Urinary Excretion of MicroRNA-126 Is a Biomarker for Hemangioma Proliferation.

ABSTRACT:

Background

Hemangiomas are unique endothelial cell tumors that involute spontaneously, which makes interpreting their response to therapies difficult. The objective of this work was to identify a potential biomarker in the urine of children with infantile hemangiomas that would facilitate testing new therapies.

Methods

A prospective longitudinal study in children with hemangiomas and age-matched healthy controls was performed to determine whether microRNA-126, which is highly abundant in fetal endothelial cells, was more abundant in the urine of affected children. Prospective ultrasound measurements of hemangioma size and blood flow velocity were obtained as secondary endpoints to document longitudinal changes in untreated hemangiomas.

Results

Urinary microRNA-126 lev

SUBMITTER: Biswas A 

PROVIDER: S-EPMC5963954 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature