Genetic Risk Score Is Associated with Vertical Cup-to-Disc Ratio and Improves Prediction of Primary Open-Angle Glaucoma in Latinos.

ABSTRACT:

Purpose

Genome-wide association studies have identified multiple genetic variants associated with vertical cup-to-disc ratio (VCDR). Genetic risk scores (GRS) examine the aggregate genetic effect of individual variants on a trait by combining these separate genetic variants into a single measure. The purpose of this study was to construct GRS for VCDR and to determine whether the GRS are associated with VCDR and whether the GRS increase the discriminatory ability for primary open-angle glaucoma (POAG) in a Latino population.

Design

Population-based genetic association study.

Participants

A total of 4018 Latino participants recruited from Los Angeles.

Methods

Weighted and unweighted GRS were constructed using 68 previously reported VCDR single nucleotide polymor

SUBMITTER: Nannini DR 

PROVIDER: S-EPMC5963986 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature