The Respiratory Environment Diverts the Development of Antiviral Memory CD8 T Cells.

ABSTRACT: Our understanding of memory CD8⁺ T cells has been largely derived from acute, systemic infection models. However, memory CD8⁺ T cells generated from mucosal infection exhibit unique properties and, following respiratory infection, are not maintained in the lung long term. To better understand how infection route modifies memory differentiation, we compared murine CD8⁺ T cell responses to a vesicular stomatitis virus (VSV) challenge generated intranasally (i.n.) or i.v. The i.n. infection resulted in greater peak expansion of VSV-specific CD8⁺ T cells. However, this numerical advantage was rapidly lost during the contraction phase of the immune response, resulting in memory CD8⁺ T cell numerical deficiencies when compared with i.v. infe

SUBMITTER: Shane HL 

PROVIDER: S-EPMC5964008 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature