The Surface-Exposed Protein SntA Contributes to Complement Evasion in Zoonotic Streptococcus suis.

ABSTRACT: Streptococcus suis is an emerging zoonotic pathogen causing streptococcal toxic shock like syndrome (STSLS), meningitis, septicemia, and even sudden death in human and pigs. Serious septicemia indicates this bacterium can evade the host complement surveillance. In our previous study, a functionally unknown protein SntA of S. suis has been identified as a heme-binding protein, and contributes to virulence in pigs. SntA can interact with the host antioxidant protein AOP2 and consequently inhibit its antioxidant activity. In the present study, SntA is identified as a cell wall anchored protein that functions as an important player in S. suis complement evasion. The C3 deposition and membrane attack complex (MAC) formation on the surface of sntA-deleted mutant strai

SUBMITTER: Deng S 

PROVIDER: S-EPMC5964162 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature