Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice.

ABSTRACT: Animals respond to environmental threats, e.g. looming visual stimuli, with innate defensive behaviors such as escape and freezing. The key neural circuits that participate in the generation of such dimorphic defensive behaviors remain unclear. Here we show that the dimorphic behavioral patterns triggered by looming visual stimuli are mediated by parvalbumin-positive (PV⁺) projection neurons in mouse superior colliculus (SC). Two distinct groups of SC PV⁺ neurons form divergent pathways to transmit threat-relevant visual signals to neurons in the parabigeminal nucleus (PBGN) and lateral posterior thalamic nucleus (LPTN). Activations of PV⁺ SC-PBGN and SC-LPTN pathways mimic the dimorphic defensive behaviors. The PBGN and LPTN neurons are co-activated by loo

SUBMITTER: Shang C 

PROVIDER: S-EPMC5964329 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature