Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study.

ABSTRACT: OBJECTIVE:To evaluate the long term association between antidepressant prescribing and body weight. DESIGN:Population based cohort study. SETTING:General practices contributing to the UK Clinical Practice Research Datalink, 2004-14. PARTICIPANTS:136 762 men and 157 957 women with three or more records for body mass index (BMI). MAIN OUTCOME MEASURES:The main outcomes were antidepressant prescribing, incidence of ≥5% increase in body weight, and transition to overweight or obesity. Adjusted rate ratios were estimated from a Poisson model adjusting for age, sex, depression recording, comorbidity, coprescribing of antiepileptics or antipsychotics, deprivation, smoking, and advice on diet. RESULTS:In the year of study entry, 17 803 (13.0%) men and 35 307 (22.4%) women with a mean age of 51.5 y

SUBMITTER: Gafoor R 

PROVIDER: S-EPMC5964332 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature