A trans-diagnostic perspective on obsessive-compulsive disorder.

ABSTRACT: Progress in understanding the underlying neurobiology of obsessive-compulsive disorder (OCD) has stalled in part because of the considerable problem of heterogeneity within this diagnostic category, and homogeneity across other putatively discrete, diagnostic categories. As psychiatry begins to recognize the shortcomings of a purely symptom-based psychiatric nosology, new data-driven approaches have begun to be utilized with the goal of solving these problems: specifically, identifying trans-diagnostic aspects of clinical phenomenology based on their association with neurobiological processes. In this review, we describe key methodological approaches to understanding OCD from this perspective and highlight the candidate traits that have already been identified as a result of these early en

SUBMITTER: Gillan CM 

PROVIDER: S-EPMC5964477 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature