Suppression of epithelial folding at actomyosin-enriched compartment boundaries downstream of Wingless signalling in <i>Drosophila</i>.

ABSTRACT: Epithelial folding shapes embryos and tissues during development. Here, we investigate the coupling between epithelial folding and actomyosin-enriched compartmental boundaries. The mechanistic relationship between the two is unclear, because actomyosin-enriched boundaries are not necessarily associated with folds. Also, some cases of epithelial folding occur independently of actomyosin contractility. We investigated the shallow folds called parasegment grooves that form at boundaries between anterior and posterior compartments in the early Drosophila embryo. We demonstrate that formation of these folds requires the presence of an actomyosin enrichment along the boundary cell-cell contacts. These enrichments, which require Wingless signalling, increase interfacial tension not only at

SUBMITTER: Urbano JM 

PROVIDER: S-EPMC5964650 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature