Interactions Between High- and Low-Risk HPV Types Reduce the Risk of Squamous Cervical Cancer.

ABSTRACT: The clinical significance of co-infections with high-risk (HR) and low-risk (LR) human papillomavirus (HPV) in the etiology of cervical cancer is debated, as prospective evidence on this issue is limited. However, the question is of increasing relevance in relation to HPV-based cancer prevention. In two population-based nested case-control studies among women participating in cervical screening with baseline normal smears, we collected 4659 smears from women who later developed cancer in situ (CIS; n = 524) or squamous cervical cancer (SCC; n = 378) and individually matched control subjects who remained free of disease during study follow-up. The median follow-up until diagnosis was 6.4 to 7.8 years. All smears were tested for HPV. We used conditional logistic regression models with two-wa

SUBMITTER: Sundstrom K 

PROVIDER: S-EPMC5964715 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature