Circulating Inflammation Markers, Risk of Lung Cancer, and Utility for Risk Stratification.

ABSTRACT: We conducted two independent nested case-control studies to identify circulating inflammation markers reproducibly associated with lung cancer risk and to investigate the utility of replicated markers for lung cancer risk stratification. Nested within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, the previously published discovery study included 526 lung cancer patients and 592 control subjects and the replication study included 526 lung cancer case patients and 625 control subjects. Control subjects were matched by sex, age, smoking, study visit, and years of blood draw and exit. Serum levels of 51 inflammation markers were measured. Odds ratios (ORs) were estimated with conditional logistic regression. All statistical tests were two-sided. Of 11 markers identified i

SUBMITTER: Shiels MS 

PROVIDER: S-EPMC5964716 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature