Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms.

ABSTRACT:

Background

There are limited data to guide clinicians in differentiating tumefactive multiple sclerosis (TMS) from CNS neoplasms. Identifying distinguishing features will inform diagnosis and management and avoid unnecessary diagnostic biopsy. Our study aimed to determine the clinical and radiologic features that differentiate TMS from glioma and CNS lymphoma (CNSL) in patients who present with tumefactive lesions.

Methods

We retrospectively reviewed all patients with tumefactive lesions and histologically proven or clinically diagnosed TMS, glioma, or CNSL at our tertiary center from 1999 to 2012. Two independent blinded neuroradiologists rated MRI brain scans at presentation. We correlated patients' demographic, clinical, laboratory, and radiologic data to final diagnosis.

SUBMITTER: Lin X 

PROVIDER: S-EPMC5964866 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature