Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis.

ABSTRACT: Previous genome-wide association studies on anthropometric measurements have identified more than 100 related loci, but only a small portion of heritability in obesity was explained. Here we present a bivariate twin study to look for the genetic variants associated with body mass index and waist-hip ratio, and to explore the obesity-related pathways in Northern Han Chinese. Cholesky decomposition model for 242 monozygotic and 140 dizygotic twin pairs indicated a moderate genetic correlation (r = 0.53, 95%CI: 0.42-0.64) between body mass index and waist-hip ratio. Bivariate genome-wide association analysis in 139 dizygotic twin pairs identified 26 associated SNPs with p < 10^-5. Further gene-based analysis found 291 nominally associated genes (P < 0.05), inclu

SUBMITTER: Wu Y 

PROVIDER: S-EPMC5964872 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature