Predicting Low Accrual in the National Cancer Institute's Cooperative Group Clinical Trials.

ABSTRACT:

Background

The extent to which trial-level factors differentially influence accrual to trials has not been comprehensively studied. Our objective was to evaluate the empirical relationship and predictive properties of putative risk factors for low accrual in the National Cancer Institute's (NCI's) Cooperative Group Program, now the National Clinical Trials Network (NCTN).

Methods

Data from 787 phase II/III adult NCTN-sponsored trials launched between 2000 and 2011 were used to develop a logistic regression model to predict low accrual, defined as trials that closed with or were accruing at less than 50% of target; 46 trials opened between 2012 and 2013 were used for prospective validation. Candidate predictors were identified from a literature review and expert interviews; f

SUBMITTER: Bennette CS 

PROVIDER: S-EPMC5964887 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature