A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions.

ABSTRACT: Boolean logic gates integrate multiple digital inputs into a digital output. Among these, logic gates based on nucleic acids have attracted a great deal of attention due to the prospect of controlling living systems in the way we control electronic computers. Herein, by employing Thioflavin T (ThT) as a signal transducer, we integrated multiple components based on RET (a type of proto-oncogene) into a logic gate combinatorial library, including basic logic gates (NOR, INHIBIT, IMPLICATION), a single three-input NOR gate, and combinatorial gates (INHIBIT-OR, NOT-AND-NOR). In this library, gates were connected in series where the output of the previous gate was the input for the next gate. Subsequently, by taking advantage of the library, some intelligent logic functions were realized. Expec

SUBMITTER: Gao RR 

PROVIDER: S-EPMC5964972 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature