Using serum troponins to screen for cardiac involvement and assess disease activity in the idiopathic inflammatory myopathies.

ABSTRACT:

Objectives

Limitations in the methods available for identifying cardiac involvement and accurately quantifying disease activity in the idiopathic inflammatory myopathies (IIMs) may contribute to poor outcomes. We investigated the utility of different serum muscle damage markers [total creatine kinase (CK), cardiac troponin T (cTnT) and cardiac troponin I (cTnI)] to address these issues.

Methods

We assessed disease activity and cardiac involvement using the International Myositis Assessment and Clinical Studies Group core set measures in 123 participants with confirmed adult-onset IIM from the UK and Denmark. Total CK, cTnT and cTnI were measured. Associations were assessed using logistic regression and Spearman's ranked correlation.

Results

Cardiac involvement (n = 18

SUBMITTER: Lilleker JB 

PROVIDER: S-EPMC5965080 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature