Novel insights into the aetiology of granulomatosis with polyangiitis-a case-control study using the Clinical Practice Research Datalink.

ABSTRACT:

Objectives

We aimed to provide insights into the aetiology of granulomatosis with polyangiitis (GPA), by conducting a large case-control study using a general population-based, prospectively collected database of healthcare records.

Methods

We compared all incident cases of GPA in the Clinical Practice Research Datalink 1990-2014, with up to 10 age-, sex- and general practice-matched controls. We identified potential risk factors, recorded numbers of cases and controls exposed to each, and calculated odds ratios (ORs) using conditional logistic regression. Our main analysis excluded data recorded during 1 year before diagnosis, to prevent early symptoms being mistaken for risk factors.

Results

We identified 757 people with GPA and matched 7546 controls. People with GP

SUBMITTER: Pearce FA 

PROVIDER: S-EPMC5965083 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature