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A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells.

ABSTRACT: The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect.

SUBMITTER: Yuan Y

PROVIDER: S-EPMC5965248 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells.

Yuan Youyong Y Zhang Chong-Jing CJ Xu Shidang S Liu Bin B

Chemical science 20151123 3

The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated <i>via</i> a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emit ...[more]

PMID: 29899908

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