Modulation of innate immunity in the tumor microenvironment.

ABSTRACT: A recent report from the Center for Disease Control identified melanoma as being among the highest causes of cancer-related mortalities in the USA. While interventions such as checkpoint blockade have made substantial impact in terms of improving response rates and overall survival, a significant number of patients fail to respond to treatment or become resistant to therapy. A better understanding of the tumor microenvironment in these patients becomes imperative for identifying immune suppressive mechanisms that impact the development of effective anti-tumor immune responses. We have investigated innate immune cells (dendritic cells, NK cells) in the tumor microenvironment (TME) in order to devise effective targeted anticancer immune therapies. We find that matrix metalloproteinase-2 (MMP

SUBMITTER: Gonzalez-Gugel E 

PROVIDER: S-EPMC5965685 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature