HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry.

ABSTRACT:

Background

Hematopoietic stem-cell transplantation (HSCT) is a potentially lifesaving therapy for several blood cancers and other diseases. For patients without a suitable related HLA-matched donor, unrelated-donor registries of adult volunteers and banked umbilical cord-blood units, such as the Be the Match Registry operated by the National Marrow Donor Program (NMDP), provide potential sources of donors. Our goal in the present study was to measure the likelihood of finding a suitable donor in the U.S. registry.

Methods

Using human HLA data from the NMDP donor and cord-blood-unit registry, we built population-based genetic models for 21 U.S. racial and ethnic groups to predict the likelihood of identifying a suitable donor (either an adult donor or a cord-blood unit) for p

SUBMITTER: Gragert L 

PROVIDER: S-EPMC5965695 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature