Functional characterization of oxazolone-induced colitis and survival improvement by vagus nerve stimulation.

ABSTRACT: BACKGROUND:Oxazolone-induced colitis has been frequently used in literature as a model of IBD, but insights into the underlying immune response and pathological features are surprisingly still very limited. Vagus nerve stimulation (VNS) has proven to be effective in innate and Th1/Th17 predominant inflammatory models, including pre-clinical models of colitis, however to what extent VNS is also effective in ameliorating Th2-driven colitis remains to be studied. In the present study, we therefore further characterized the immune response in oxazolone-induced colitis and investigated the potential therapeutic effect of VNS. METHODS:Colitis was induced in Balb/c mice by cutaneous sensitization with 3% oxazolone followed by intracolonic administration of 1% oxazolone 7 days later. To evaluate t

SUBMITTER: Meroni E 

PROVIDER: S-EPMC5965883 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature