Disruption of the Microglial ADP Receptor P2Y₁₃ Enhances Adult Hippocampal Neurogenesis.

ABSTRACT: In mammalian species, including humans, the hippocampal dentate gyrus (DG) is a primary region of adult neurogenesis. Aberrant adult hippocampal neurogenesis is associated with neurological pathologies. Understanding the cellular mechanisms controlling adult hippocampal neurogenesis is expected to open new therapeutic strategies for mental disorders. Microglia is intimately associated with neural progenitor cells in the hippocampal DG and has been implicated, under varying experimental conditions, in the control of the proliferation, differentiation and survival of neural precursor cells. But the underlying mechanisms remain poorly defined. Using fluorescent in situ hybridization we show that microglia in brain express the ADP-activated P2Y₁₃ receptor under basal conditio

SUBMITTER: Stefani J 

PROVIDER: S-EPMC5966569 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature