Association of Cerebral Microbleeds With Cognitive Decline and Dementia.

ABSTRACT:

Importance

Cerebral microbleeds are hypothesized downstream markers of brain damage caused by vascular and amyloid pathologic mechanisms. To date, whether their presence is associated with cognitive deterioration in the general population remains unclear.

Objective

To determine whether microbleeds, and more specifically microbleed count and location, are associated with an increased risk for cognitive impairment and dementia in the general population.

Design, setting, and participants

The Rotterdam Study, a prospective population-based study set in the general community, assessed the presence, number, and location of microbleeds at baseline (August 2005 to December 2011) on magnetic resonance imaging studies of the brain in 4841 participants 45 years or older. Partici

SUBMITTER: Akoudad S 

PROVIDER: S-EPMC5966721 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature