Transcriptional profiling reveals gland-specific differential expression in the three major salivary glands of the adult mouse.

ABSTRACT: RNA-Seq was used to better understand the molecular nature of the biological differences among the three major exocrine salivary glands in mammals. Transcriptional profiling found that the adult murine parotid, submandibular, and sublingual salivary glands express greater than 14,300 protein-coding genes, and nearly 2,000 of these genes were differentially expressed. Principle component analysis of the differentially expressed genes revealed three distinct clusters according to gland type. The three salivary gland transcriptomes were dominated by a relatively few number of highly expressed genes (6.3%) that accounted for more than 90% of transcriptional output. Of the 912 transcription factors expressed in the major salivary glands, greater than 90% of them were detected in all three gland

SUBMITTER: Gao X 

PROVIDER: S-EPMC5966806 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature