The role of human Metapneumovirus genetic diversity and nasopharyngeal viral load on symptom severity in adults.

ABSTRACT:

Background

Human metapneumovirus (HMPV) is established as one of the causative agents of respiratory tract infections. To date, there are limited reports that describe the effect of HMPV genotypes and/or viral load on disease pathogenesis in adults. This study aims to determine the role of HMPV genetic diversity and nasopharyngeal viral load on symptom severity in outpatient adults with acute respiratory tract infections.

Methods

Severity of common cold symptoms of patients from a teaching hospital was assessed by a four-category scale and summed to obtain the total symptom severity score (TSSS). Association between the fusion and glycoprotein genes diversity, viral load (quantified using an improved RT-qPCR assay), and symptom severity were analyzed using bivariate and line

SUBMITTER: Oong XY 

PROVIDER: S-EPMC5966857 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature