Essential genes of the macrophage response to Staphylococcus aureus exposure.

ABSTRACT:

Background

Although significant advances have been made in understanding the mechanisms of macrophage response to Staphylococcus aureus infection, the molecular details are still elusive. Identification of the essential genes and biological processes of macrophages that are specifically changed at different durations of S. aureus exposure is of great clinical significance.

Methods

We aimed to identify the significantly changed genes and biological processes of S. aureus-exposed macrophages. We systematically analyzed the macrophage gene expression profile GSE 13670 database with 8 h, 24 h or 48 h S. aureus infection. The results were further confirmed by western blot and quantitative polymerase chain reaction (qPCR) analyses.

Results

After

SUBMITTER: Sun A 

PROVIDER: S-EPMC5966896 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature