Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation.

ABSTRACT:

Background

Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO₂NPs) have the ability to modify disease outcome but have not been investigated for their effect on models of asthma and inflammatory lung disease. The aim of this study was to examine the impact of CeO₂NPs in a house dust mite (HDM) induced murine model of asthma.

Results

Repeated intranasal instillation of CeO₂NPs in the presence of HDM caused the induction of a type II inflammatory response, characterised by increased bronchoalveolar lavage eosinophils, mast cells, total plasma IgE and goblet cell metaplasia. This was accompanied by increases in IL-4, CCL11 and MCPT1 gene expression together with incr

SUBMITTER: Meldrum K 

PROVIDER: S-EPMC5966909 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature