Histone modifications and their role in epigenetics of atopy and allergic diseases.

ABSTRACT: This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development. Together with DNA methylation, histone modifications (including histone acetylation, methylation, phosphorylation, ubiquitination, etc.) represent the classical epigenetic mechanisms. However, much less attention has been given to histone modifications than to DNA methylation in the context of allergy. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of histone modifications in allergy and the mechanisms underlying this development. In addition to covering the growing interest in the contribution of histone m

SUBMITTER: Alaskhar Alhamwe B 

PROVIDER: S-EPMC5966915 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature