An inhibitory pull-push circuit in frontal cortex.

ABSTRACT: Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.

SUBMITTER: Garcia-Junco-Clemente P 

PROVIDER: S-EPMC5967235 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature