Synthesis of E- and Z-trisubstituted alkenes by catalytic cross-metathesis.

ABSTRACT: Catalytic cross-metathesis is a central transformation in chemistry, yet corresponding methods for the stereoselective generation of acyclic trisubstituted alkenes in either the E or the Z isomeric forms are not known. The key problems are a lack of chemoselectivity-namely, the preponderance of side reactions involving only the less hindered starting alkene, resulting in homo-metathesis by-products-and the formation of short-lived methylidene complexes. By contrast, in catalytic cross-coupling, substrates are more distinct and homocoupling is less of a problem. Here we show that through cross-metathesis reactions involving E- or Z-trisubstituted alkenes, which are easily prepared from commercially available starting materials by cross-coupling reactions, many desirable and otherwise diffic

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC5967255 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature